Mechanism From the abstract: Following metabolic activation, aristolochic acid reacts with DNA to form aristolactam (AL)-DNA adducts. These lesions concentrate in the renal cortex, where they serve as a sensitive and specific biomarker of exposure, and are found also in the urothelium, where they give rise to a unique mutational signature in the TP53 tumor-suppressor [...]
Categories: Medicine
Tagged: Aristolochia clematis, aristolochia plants, Aristolochic acid, Arthur P. Grollman, Asian medicine, Balkans, Chung-Hsin Chen, Dmitri V. Gnatenko, Jiri Zavadil, Karen L. Edwards, Kathleen G. Dickman, kidney, Lin Wu, Masaaki Moriya, nephropathy, p53, renal cell, Robert J. Turesky, Taiwan, TP53, transitional cell, tumor suppressor, upper urinary tract, urothelial carcinoma, Viktoriya S. Sidorenko, Xue-Ru Wu, Yeong-Shiau Pu