Demonstrating molecular biology’s specificity and usefulness From the abstract: [A] complementary single atom exchange in the vancomycin core structure (O → NH) to counter the single atom exchange in the cell wall precursors of resistant bacteria (NH → O) reinstates potent antimicrobial activity and charts a rational path forward for the development of antibiotics for [...]
Tagged: Akinori Okano, anti-microbial, antibiotic, binding, biochemist, cell wall, complementary, d-Ala, d-Lac, Dale L. Boger, disease, drug, drug resistance, Jian Xie, Joshua G. Pierce, last resort, lock and key, NH, O, pharmaceutical, proton, resistance, Robert C. James, site, substitution, Vancomycin