Caffeine apparently interferes with harmful effects of the ATR-Chk1 pathway in skin cells Researchers have been aware that drinking caffeinated beverages reduces the incidence of non-melanoma skin cancers. And they knew that applying caffeine topically to un-diseased skin, as well as skin cancer tumors, in mice reduced the number of tumors in comparison with untreated [...]
Tagged: A H Conney, Alessandra Blasina, Allan H Conney, ATR–Chk1 Pathway Inhibition Promotes Apoptosis after UV Treatment in Primary Human Keratinocytes: Potential Basis for the UV Protective Effects of Caffeine, Caffeine Decreases Phospho-Chk1 (Ser317) and Increases Mitotic Cells with Cyclin B1 and Caspase 3 in Tumors from UVB-Treated Mice, gene, Kenna Anderes, Masaoki Kawasumi, p53, Paul Nghiem, Q Y Peng, Timothy P Heffernan, tumor suppressor, Y P Lu, Y R Lou